A USB can pretend to be just about any type of device to get the appropriate driver installed and loaded. They can then send malformed packets to that driver to trigger some vulnerability and take over the system.
There are a _lot_ of drivers for devices on a default windows install. There are a _lot more_ if you allow for Windows Update to install drivers for devices (which it does by default). I would not trust all of them to be secure against a malicious device.
I know this is not how stuxxnet worked (instead using a vulnerability in how LNK files were shown in explorer.exe as the exploit), but that just goes to show how much surface there is to attack using this kind of USB stick.
And yeah, people still routinely plug random USBs in their computers. The average person is simultaneously curious and oblivious to this kind of threat (and I don't blame them - this kind of threat is hard to explain to a lay person).