A niche Wine does suit well is running audio plugins for music production.
Wouldn't have believed it if I didn't first see and then use it myself.
Think it's because JUCE is relatively well-supported on Wine and natively on Linux, there are hardly any dependencies outside of system libraries and a DSP library.
Yeah, it's pretty mind-blowing how well this works, even though the setup was a bit janky.
Sadly, after moving my music production setup from Windows to Linux, I'm locked out of some of my expensive sample libraries because while the plugins run fine, the licensing programs do not. Very frustrating.