alt Hacker NewsEdit: disregard. I read it as he'd done it and had contention problems.
You can't. You have a single writer - it's one of the many reasons sqlite is terrible for serious work.
You'll need a multiprocessing Queue and a writer that picks off sentences one by one and commits it.
This is just untrue - the naive implementation (make the API call, write a single row to the db) will work fine, as transactions are quite fast on modern hardware.
What do you consider "serious" work? We've served a SaaS product from SQLite (roughly 300-500 queries per second at peak) for several years without much pain. Plus, it's not like PG and MySQL are pain-free, either - they all have their quirks.