These are my PRAGMAs and not your PRAGMAs. Be very careful about blindly copying something that may or may not match your needs.

    PRAGMA foreign_keys=ON
    PRAGMA recursive_triggers=ON
    PRAGMA journal_mode=WAL
    PRAGMA busy_timeout=30000
    PRAGMA synchronous=NORMAL
    PRAGMA cache_size=10000
    PRAGMA temp_store=MEMORY
    PRAGMA wal_autocheckpoint=1000
    PRAGMA optimize <- run on tx start

Note that I do not use auto_vacuum for DELETEs are uncommon in my workflows and I am fine with the trade-off and if I do need it I can always PRAGMA it.

defer_foreign_keys is useful if you understand the pros and cons of enabling it.