alt Hacker NewsTraumatic events, like NDEs, tend to come with lots of adrenaline, stress hormones, and a cocktail of neurotransmitters that could have the secondary consequence of slowing overall monoamine oxidation, similar to MAOIs, resulting in longer effective exposure to any chemicals like DMT that would normally be transient.
You at most have around 250 μg in your system, you need at least 40 times that to get to the lower threshold of a psychedelic effect. If other factors are in play, and it doesn't get immediately metabolized because of everything else consuming the MAO supply, then it's plausible that there could be an effect.
If that were the case, then you're looking at a potential last-ditch survival mechanism, reinforcing the experience and "fuzzing" the memory for maximum impact.
There is evidence for a surge in DMT production in some rats upon death:
> In our previous studies, we have observed a marked elevation of some, but not all, critical neurotransmitters in rat brain during asphyxic cardiac arrest21, which we posit may contribute to the elevated conscious information processing observed in dying rats21,49. These data also suggest that global ischemia (by cardiac arrest, as in the current study), similar to global hypoxia (by asphyxia, as in21), leads to a tightly regulated release of a select set of neurotransmitters21. To test whether DMT concentrations are regulated by physiological alterations, we monitored DMT levels in rat brain dialysates following experimentally-induced cardiac arrest, and identified a significant rise in DMT levels in animals with (Fig. 4A) and without the pineal (Fig. 4B).
> The cardiac arrest-induced increase of endogenous DMT release may be related to near-death experiences (NDEs), as a recent study reports NDE-like mental states in human subjects given exogenous DMT50. Not all rats in our current study exhibited a surge of DMT following cardiac arrest (Fig. 4), an interesting observation in light of the fact that NDEs are reported by less than 20% of patients who survive cardiac arrests.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6088236/
Presumably only 20% of the rats were religious.