Substituted amphetamines were already very popular in the 1950s.
And had been researched treat symptoms of depression and what would eventually be called ADHD in the 1930's.
... and I didn't know about them:
https://en.wikipedia.org/wiki/Substituted_amphetamine
The most famous in that family seems to be meth(amphetamine)
Methamphetamine was invented in Germany in 1937 and the German military at the time was very quick to adopt its use.