I upgraded my home backup server a couple of months ago to a Minisforum N5 Pro, and am very happy with it. It only has 4 3.5” drive slots, but I only use two with 2x20TB drives mirrored, and two 14TB external drives for offsite backups. The AMD AI 370 CPU is plenty fast so I also run Immich on it, and it has ECC RAM and 10G Ethernet.
The N5 Pro is a good machine, but I have to recommend the Aoostar WTR Max over it, having used both. It's a few hundred bucks cheaper ($680 post-tax for a quality SFF case + mobo + CPU + power + fans!!) and has an extra drive bay and a couple of additional NVMe slots (three Gen4 2x and two 1x), despite being only ~13% larger. Also, the drive caddies on the N5 Pro were driving me crazy: the plastic clips holding the disk in place require quite a bit of force to dislodge and feel like they could snap at any moment. (And once they inevitably do, there's no screwholes to use as a backup.)
Either way, it's a great time for home NAS.