The term "slave" encompasses a lot of wildly different kinds of unfree labor. The racialized system most people think of from transatlantic slavery is a very recent thing.
Nothing resembling that was widespread in precolumbian North America. The earliest similar systems I'm aware of took root in the 17th and 18th centuries, well into the early colonial period.
Research what the Iroquois did to the Huron people, what the Apache did to the Pueblos, and what the Aztecs did to everybody.
The continent what a slaughter show for thousands of years.