This is quite easy with OpenWRT.
Install the Wireguard packages, create a connection to your VPN of choice in a nearby country (I chose Sweden). Then I used the "vpn-policy-routing" package to route Imgur IPs (199.232.196.193 199.232.192.193) through the VPN.
Works for websites that keep nagging you for age verification too.
But seriously, it's been more emotional than I'd expected to get my cat memes back.
Didn't even know it was possible. But thanks to this comment - got the same setup via my Unifi router too. Thanks!
Yeah, doing it with OpenWRT and PBR is definately much simpler than this approach. However by using hard-coded IP addresses you are at risk of breakage if they change in the future.
Also fastly-hosted services are a bit awkard to configure IP ranges to cover whole blocks as they seem to not use normal CIDR-blocks for different customers.
But you use PBR's ntfset functionality to have your dns server automatically update a set whenever an DNS entry is resolved, then set the policy rules based on the set.