I have polymorphisms in a gene called CYP2R1 (Vitamin D 25-hydroxylase, involved in activation of vitamin D precursors). My polymorphism lead to lower levels of D3.

My doc put me on 1000mcg of D3 a day for a month after I tested low. I came back in for blood testing and my Calcium levels were extremely high (Not good!). So the doctor ordered me to stop the vitamin D to see what was going on.

As it turns out I have even more lower frequency polymophisms in a gene called CALCA (Calcitonin is a peptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.). So basically since I do not realease a lot of Calcitonin naturally I need to get it from food.

Guess what food is extremely high in Vitamin D3[1] and Calcitonin[2]?

Salmon! I have a genetic history of people that ate a lot of salmon so this makes sense.

Genetics matter people. I will assume that most people who have irish/britsh should be getting their D3 from fatty fish since sunlight is so rare there.

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC6566758/ [2] https://en.wikipedia.org/wiki/Salmon_calcitonin).