> Cheating is a meat space problem and there is no technical solution to it

Cheating is an arms race - the number of people who are willing to run a second computer with DMA connected to a single machine is vastly smaller than the number of people who are wiling to download a dodgy file from the internet and run it.

> Ultimately it comes down to checking if metrics like reaction speed are humanly possible, but a rootkit is not really needed for that.

If it was that easy, cheating would be a solved problem. An awful lot of play is "I know the reload time is 0.75s, so they're going to appear when they've reloaded" - that's way beyond human reaction time. And that's at "mid level" play - at gold/sliver levels in league of legends knowing cooldowns is considered base knowledge. At higher levels of play, _all_ of your players are statistical outliers.