Main issue is the lack of Vulkan support on macOS. Currently, solutions like MoltenVK have to be developed to add Vulkan support, which isn't as clean as just supporting it.
For some reason the prospect using Wine, Rosetta 2, and DXVK with MoltenVK on top just to run some games doesn't inspire a lot of confidence that this whole thing will be performant and/or stable.
No, the main issue is a fundamentally different rendering pipeline (tile based deferred rendering) that makes "Vulkan support" a conceptually difficult square peg in a round hole problem, since everything is made for immediate rendering, like all the other mainstream GPUs use.