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hedorayesterday at 6:19 PM3 repliesview on HN

Shingles attacks your nervous system. Avoiding shingles prevents it from damaging your brain, so it isn’t surprising the vaccine reduces dementia.

There are multiple causes for dementia. If I read figure 2 right, the vaccine slightly reduces the chance of mild cognitive impairment, but cuts the chances of dying from dementia by about a third(!)

Also interesting: The vaccine helps at different phases of disease progression.

The simplest explanation is that dementia is due to cumulative damage, not a single event, and that getting shingles is a big hit.

The vaccine probably prevents dementia in the same way staying out of planes makes you invulnerable to parachute failures.


Replies

_alternator_yesterday at 6:24 PM

The emerging evidence, taken together, shows a ~20% reduction in dementia over 7 years. So it’s actually pretty dramatic. https://med.stanford.edu/news/all-news/2025/03/shingles-vacc...

wdbyesterday at 6:25 PM

What do they mean with 'dying from dementia'? As typically you don't die from dementia but something like pneumonia or something else. Personally, I wouldn't wish dementia on anyone and definitely wouldn't want to extend my life while having dementia.

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jtbaylyyesterday at 6:24 PM

A lot of dead BASE jumpers disagree...