The punishment for crimes in Altered Carbon was sending you to a far enough future so you know nothing and no one. With age you get alienated in a similar way, maybe adding (lack of) understanding on the mix. Your brain have limits, your adaptability have limits, your physiology have limits, pushing them forward doesn't take them out. Eventually you get tired, bored, or want to get out. At least speaking about most and not special cases (I hope).

And having a simulation of ourselves in a different media is a different game.