They were big in software for the one laptop per child project:

https://www.rit.edu/news/rit-class-develops-applications-sup...

And, while not open source, built this: https://dirsig.cis.rit.edu/

Also, I remember some kind of early realtime music accompaniment software, the guy played trumpet and the software played realtime accompaniment.

Also, MIT built X11, which later turned into a bureaucratic exercise instead of software project.

Berkeley, well BSD Unix.

Early web projects came out of Michigan, like gopher.

Not much lately though.