To be precise, we're talking about "Desktop Computers" and not the more generic "information appliances".
For example, we're not remotely close to having a standardized "watch form-factor" appliance interface.
Physical reality is always a constraint. In this case, keyboard+display+speaker+mouse+arms-length-proximity+stationary. If you add/remove/alter _any_ of those 6 constraints, then there's plenty of room for innovation, but those constraints _define_ a desktop computer.
That's just the thing, desktops computers have always been in an important way the antithesis of a specialized appliance, a materialization of Turing's dream of the Universal Machine. It's only in recent years that this universality has come under threat, in the name of safety.