I use both uBO and NoScript and wondered if I really needed uBO if I blocked YouTube as I've planned.
However, it leads to Mozilla's earlier weird design choice where you have to install addon if you only want to disable JavaScript on sites - or allow it from only the selected domains.
Years later I haven't found a sensible explanation why they ditched that choice.
I've understood that you can still do it in Chrom(e/ium) and combined with a good updated blocklist in /etc/hosts or like it would provide most of the functionality of an adblock.
On my desktop i use just NoScript and i do not need uBO, as almost no ad is shown without JS.