alt Hacker News>These three disorders could really be “CKM syndrome,” which can be treated with drugs like Ozempic
The article is trying so hard not to say that obesity is the cause. I call it the obesity pipeline: You start off young and obese and you don't have diabetes and it's all fine. Stay obese long enough and you get diabetes -> metformin. Stay in a diabetic state long enough and you get heart disease -> statins. These are obesity comorbidities.
Replies
e40 • last Thursday at 7:50 PM
What does metformin have to do with it? I'm not obese, but I'm on metformin.
lawlessone • last Thursday at 9:16 PM
I think obesity just speeds up the onset, plenty of older skinny people with heart disease.
This is just my unqualified opinion to be clear
There is an alternative possibility: you start out with a metabolic disorder, that will eventually grow into diabetes. Along the way, it will make you obese and cause (directly or indirectly) heart and kidney problems.
Unfortunately, since Ozempic treats diabetes with or without obesity, and it also treats obesity without diabetes, it won't help us figure out if obseisty is a cause or a side effect of diabetes. But there really is little reason to pretend it's clear either way.