The Looker is quite possibly the greatest parody ever executed in a video game. It creates the same kind of "ahah" moment that games like The Witness do, but in a way that really pokes fun at the level of pretentiousness those games tend to indulge themselves in.
I've heard The Looker described as "If you liked The Witness, you'll like The Looker. If you hated The Witness, you'll love The Looker."
I never found The Witness to be pretentious, but I still think The Looker is a great parody.
It's the gaming version of Galaxy Quest: a parody that is not only great when it stands by itself, but is satirical in a way that shows they are genuinely big fans of the source material.
(Though perhaps unsurprisingly, Blow has only once mentioned The Looker, saying he hates how it devalues his art, and now refuses to talk about it ever.)