As with most 40+GbE ports, the 400Gbit ports can be split into 2x200Gbit ports with the use of special cables. So you can connect a total of 6 machines at 200Gbit.
Breakout cables typically split to 4.
e.g. QSFP28 (100GbE) splits into 4x SFP28s (25GbE each), because QSFP28 is just 4 lanes of SFP28.
Same goes for QSFP112 (400GbE). Splits into SFP112s.
It’s OSFP that can be split in half, i.e. into QSFPs.
Ah, good point. Though if splitter cables are an option, then it seems more likely that the 50G ports could be combined into a 200G cable. Marvell's product brief for that switch chip does say it's capable of operating as an 8x 200G or 4x 400G switch, but Mikrotik may need to do something on their end to enable that configuration.