I dont know what would be the best way, but I personally want each image to be represented correctly in relation to all other image. This means that the way images are laid out will looked jagged. However, as a consequence of that, it is easy to find back to a specific image. Its like when you are coding, you look at the "shape" of the code when scrolling to find that specific function definition etc..
Here is an example of the layout of a photostream that I was satisfied with.
https://frifoto.emilbratt.no/?view_mode=photo-stream&tag=All...