I think a big piece missing from these conversations is compliance frameworks and customer trust. Of your selling to enterprise customers or governments, they want to go through your stack, networking, security, audit logs, and access controls with a fine toothed comb.

Everything you do that isn't "normal" is another conversation you need to have with an auditor plus each customer. Those eat up a bunch of time and deals take longer to close.

Right or wrong, these decisions make you less "serious" and therefore less credible in the eyes of many enterprise customers. You can get around that perception, but it takes work. Not hosting on one of the big 3 needs to be decided with that cost in mind