I usually do REPL driven development in Python via emacs but you can tell it's not the natural way to do things, esp. if you start doing stuff with async. But I still feel that it makes me way more productive than I would otherwise be

It has a Tk based REPL and debugger in the box, and I guess nowadays Jupiter notebooks is the closest to a Lisp Machines/Interlisp-D kind of development.

There are the IDE integrations as well.

Pity is the lack of (compile ...) and (decompile ....), or similar.

Which by the way is available in Julia.