The article does address that:

> Unfortunately, it’s not just delayed ACK2. Even without delayed ack and that stupid fixed timer, the behavior of Nagle’s algorithm probably isn’t what we want in distributed systems. A single in-datacenter RTT is typically around 500μs, then a couple of milliseconds between datacenters in the same region, and up to hundreds of milliseconds going around the globe. Given the vast amount of work a modern server can do in even a few hundred microseconds, delaying sending data for even one RTT isn’t clearly a win.