I'm not sure how environmental factors play into this either. As a Gen-Xer, it often feels like the current late teens and early 20-somethings all have a crippling level of "anxiety" over what should be relatively simple human interaction, and this started well before COVID solidified this influence. Does this in general have an outsized effect on burnout?

I've felt true burnout twice in my life, the first time was after several years without any vacation time taken and about 3 months of 60-80 hour weeks. I literally hit a wall and couldn't even open a project in front of the computer, I was in a haze and not safe to even do anything. My brain was like, "nope!" More recently, a couple years ago it's been a larger state of dissolution about my career without a clear alternative so much as something that I would consider a disablement.