Make a list of the most interesting companies / areas you want to work in from a scientific perspective

Cold call or get introductions to their R&D leaders (principal researcher /director / VP). While connecting to something they or their company did, ask for a coffee meeting or phone call to learn more about their company and how it works.

Use this to Network network network. At some point a job will appear with interviews. Chances are good it’s with a good manager as they’re the ones taking time to build good teams and talent.