I recall a University of Washington (I think it was) where they were saying they had found Schizophrenia to be a bucket diagnosis, and had discovered that multiple sets of genes were working together in specific testable ways such that there were >4 sub types of Schizophrenia each with its own set of symptoms, and ability to respond to different medications.

The researcher did a follow-up study to confirm their thesis, but I've never seen anyone else follow up on those studies (family with Schizophrenia makes me acutely aware of developments in that field)

https://source.washu.edu/2014/09/schizophrenia-not-a-single-...

oh, would you look at that - a newer study https://biology.ucdavis.edu/news/discovery-hints-genetic-bas...