You can if you just run PTP (almost) entirely on your NIC. The best PTP implementations take their packet timestamps at the MAC on the NIC and keep time based on that. Nothing about CPU processing is time-critical in that case.
Well, if the goal is for software running on the host CPU to know the time accurately, then it does matter. The control loop for host PTP benefits from regularity. Anyway NICs that support PTP hardware timestamping may also use PCI LTR (latency tolerance reporting) to instruct the host operating system to disable high-exit-latency sleep features, and popular operating systems respect that.
Well, if the goal is for software running on the host CPU to know the time accurately, then it does matter. The control loop for host PTP benefits from regularity. Anyway NICs that support PTP hardware timestamping may also use PCI LTR (latency tolerance reporting) to instruct the host operating system to disable high-exit-latency sleep features, and popular operating systems respect that.