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UniverseHackeryesterday at 3:33 PM2 repliesview on HN

If white fat converts to beige fat, it is going to be burning a lot more calories, so you ultimately would have to eat more to maintain a stable body weight. It’s not clear to me that this would negate the benefit.

If it does negate the benefit than that would suggest that the entire benefit from the beige fat is from putting the body in a calorie deficit, and you would then expect the exact same effectiveness from calorie restriction. A quick search shows that there does seem to be an anti cancer therapeutic benefit from calorie restriction, so this seems at least plausible.

So this raises the research question of if increasing calorie intake to keep weight stable completely negates the anti-cancer benefits of increased beige fat or not. I’m curious if that has been investigated yet.


Replies

blensoryesterday at 6:09 PM

I recently saw a video discussing fasting effects on cancer.

In the past it seems the consensus was that since cancer cells need more fuel than regular cells, starving them is beneficial in combating it.

But recently it has been discovered that some cancers can grow better with ketones.

So it seems that some cancers benefit from fasting while others are starved from fasting.

bratwurst3000yesterday at 3:44 PM

in all respect sorry this is wrong. this is a broad misinformation. It can enhance but also supresse cancer dependig of soo much we dont know yet enough to know if fasting is beneficial or dangerous.

https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.5577

edit:// and the article has imho nothinh to do with autophagy. Its about beige fat cells eating stuff away from cancer not autophagy wich happened in the innercell. And if you go into caloric deficit you could burn away those beige fat cells that "heal" the cancer.

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