I see no reason why both parties should not try.
Nikki Haley did very well in the primary against a more well known Ron DeSantis & Chris Christie. We have had multiple governors.
The only 2 that have run are not a good example.
A lot of people had strong opinions on Hillary that had nothing to do with her politics or leadership. A lot didn't want another 4-8 years of Clinton/Bush after 28 years depending on how you count Bush Sr. You could even add another 4 to that for Hillary's 4 yrs of influence as Secretary of State.
Harris wasn't popular in the primaries, many thought she wasn't deserving of the VP & she was part of an unpopular White House that was given a few ticking time bombs that they didn't properly diffuse. They also failed miserably to communicate with the public.