Inline script metadata itself is not tied to uv because it's a Python standard. I think the association between the two comes from people discovering ISM through uv and from their simultaneous rise.

pipx can run Python scripts with inline script metadata. pipx is implemented in Python and packaged by Linux distributions, Free/Net/OpenBSD, Homebrew, MacPorts, and Scoop (Windows): https://repology.org/project/pipx/versions.