Maybe I "entered" the Python ecosystem at a different time, but I never used virtualenvwrapper.sh nor sat PYTHONPATH manually ever. When I first came into contact with Python, I think doing `virtuelenv venv && source venv/bin/activate` was what was recommended to me at the time. Eventually I used `python -m venv` but always also with `pip` and a `requirements.txt`. I pretty much stuck with that until maybe 1 year ago I started playing around with `uv`, and for me, I just use `uv venv|pip|init|add` from uv, and nothing else from any other tools, and generally do pretty basic stuff.

Maybe for more complex projects and use cases it's harder, but it's a lot faster than just pip and pyproject.toml is a lot nicer to manage than `requirements.txt`, so that's two easy enough wins for me to move over.