> When considering NAC's mechanisms, it seems that it's efficacy is likely dependent on an individuals's glutathione status.

NAC interacts with a lot of things. Not just glutathione.

It modulates glutamate activity in the brain. That’s a key neurotransmitter. It’s why it can be helpful in some specific psychiatric conditions, but also why many people discovering it to be cognitively dulling or to induce blunt effect.

It also interacts with trace minerals in your body. Taking it for a long time can reduce these levels, creating multiple secondary problems.

The list of things it does goes on and on. It’s not a simple supplement for glutathione.