Agreed, and on top of that:

I think these kind of numbers are everywhere and not just specific to Python.

In zig, I sometimes take a brief look to the amount of cpu cycles of various operations to avoid the amount of cache misses. While I need to aware of the alignment and the size of the data type to debloat a data structure. If their logic applies, too bad, I should quit programming since all languages have their own latency on certain operations we should aware of.

There are reasons to not use Python, but that particular reason is not the one.