I've just finished the base install of Gentoo on my brand new Framework 16 and I still wonder why I didn't make the move sooner.
Hardware: HX370, 128G RAM, Radeon 860M iGPU, Radeon RX7700S dGPU, Xbox Wireless Cntroller, 2T + 8T SSD storage
Software (as of today, still making additions and refinements): Gentoo/OpenRC (I don't like systemd), Kernel 6.12.58 with additional module for the Xbox controller, Pipewire+EasyEffects 8, KDE Plasma 6.5.4/Wayland, Steam
Experience: KDE runs pretty stable, and only has the things I really need (and not the things a vendor thinks I need).
The first game I benchmarked today was Doom (2016), which runs smoothly on 90-120 fps on high settings.
The second game I benchmarked today was Indiana Jones and the Great Circle (2024) running on ~56fps on recommended settings on the 7700.
The one game I tried today and could not get to run properly was Stalker 2: Heart of Chernobyl. I suspect that, given the many positives on ProtonDB, that's mainly either a configuration or Proton issue. I'll do some more research and give it another try in the near future. Right now performance drops to 5 fps immediately after starting a new game, and the CPU running on 600Mhz maximum when starting the game on Proton Experimental.
For now I am quite happy with the results, and the fact that I likely finally am able to eject Windows out of my life.