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stacktrustlast Sunday at 4:32 PM3 repliesview on HN

> Osteoarthritis occurs when a joint is stressed by aging, injury or obesity. The chondrocytes begin to release pro-inflammatory molecules and to break down collagen, which is the primary structural protein of cartilage. When collagen is lost, the cartilage thins and softens; the accompanying inflammation causes the joint swelling and pain that are hallmarks of the disease.

Collagen synthesis in the human body can be aided by hydrolyzed collagen, Vitamin C, zinc and copper.


Replies

rjdj377dhabsnlast Monday at 5:45 AM

A recent meta analysis suggests the positive results for collagen are mostly funding bias. See discussion here:

https://massresearchreview.com/2025/09/29/connecting-the-dot...

I have been taking collagen, but will likely stop.

chrisfosterellilast Sunday at 6:38 PM

Among endurance athletes collagen supplements have become increasingly popular the past couple years -- from what I understand the evidence is kind of mixed though

e.g. https://thefeed.com/products/pillar-performance-collagen-1?v...

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rixedlast Sunday at 5:43 PM

Evidence seems to be lacking though. Do you have any specific source in mind?

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