How do you imagine that? First thing coming to mind is the loudness of rocket starts and powered landings. Even for airports that would be too loud. At least with current regulations. So you'd probably waste time getting to some dedicated facility, far out in the midst of nowhere to care about, and getting out of a similar hole on the other side of the trip. And again regulations regarding the closure of airspaces and seas for starts and landings, as it's currently done. Which seems rather incompatible with the current system of commercial flight ops, as it's currently done. Other relevant regulations coming to mind are evacution procedures/general survivability provisions for conventional commercial flights, which are mandatory by law.

However I turn that idea, no matter from which point I'm looking at it, I'm not seeing it going anywhere.