Attaching an air sensor to a giant high-speed fan is not going to help you pinpoint anything, it's just going to blow the air around.

Getting accurate room-based location requires even turning the HVAC off and avoiding a lot of walking through a building.

UAS move a lot of air - I can't imagine this would be practical. At the very least, you'd need to put the sensor on a boom long enough to make it unwieldy.