I am doubtful of the scientific validity and am definitively not dismissive of cultures that use meditations for inquiry into Self.
Strength training is a good example because it is an immensley stressful activity with adaptations that sometimes go into tics.
I believe I’ve read accounts of experienced meditators also stressing themselves to the verge of lunacy. Some even deal with panic attacks , unannounced, despite lecturing on inner peace.
There are claims and links to scientific studies in this article.
https://www.skepticspath.org/blog/what-is-the-science-of-med...
Dedicated mediators sometimes experience signs and symptoms of psychosis
https://pmc.ncbi.nlm.nih.gov/articles/PMC8380174/
In general psychosis-proneness is a quantity that people have more or less, some people have harmless hallucinations or "unusual experiences" but psychosis-prone people have more trouble when they are under more stress. Some researchers think that meditation practice could be protective
https://www.nature.com/articles/s41599-023-01856-y
Personally mindless use of the word "mindful" is a pet peeve of mine because I knew somebody who would talk about mindfulness just before he walked into an open pit. Also back when I was more anxious I always thought my mind was "full" by default and wanted to empty it, I found that many practices would just fill my mind up with more noise.