The comparison with WINE is quite apt, though. Although it is using a 68000 emulator, unlike WINE which is purely native code, it is taking the same approach to implementing AmigaOS as WINE took to implementing Windows: it offers the normal API entrypoints, and as soon as programs call into them, it takes over and does things natively.

VAMOS writes as few 68000 instructions into the emulator's memory as possible; as soon as the program calls an AmigaOS API, the emulator traps it and handles the implementation in Python.