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Dumblydorryesterday at 2:26 PM2 repliesview on HN

Citation? Sounds dubious


Replies

rootusrootusyesterday at 4:37 PM

There are a couple recent stories that people put on weight something like 4x as fast if they go cold turkey after a GLP1 than if they quit a normal starvation diet. This intuitively makes sense, because an average GLP1 weight loss is way higher than most people can attain with willpower alone. So when they stop, the body screams "feeeeeeed me!" at incredible volume.

buellerbuelleryesterday at 7:18 PM

https://www.bmj.com/content/392/bmj-2025-085304

"This review found that cessation of WMM [weight management medication] is followed by rapid weight regain and reversal of beneficial effects on cardiometabolic markers. Regain after WMM was faster than after BWMP [behavioral weight management programs]. These findings suggest caution in short term use of these drugs without a more comprehensive approach to weight management."