alt Hacker NewsI don't know that there's a consensus on what the limit really is. Semaglutide is good for about 15%, tirzepatide about 20%, and retatrutide about 25%. Some people don't get that much, some people get a lot more. Personally, tirzepatide got me just over 35%. I never got anywhere near max dose, either, I am what is colloquially referred to as a super responder.
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vladgur • today at 4:40 AM
Sorry for personal questions please answer any OR none as you feel comfortable
1) How is your energy/stamina following the 35% loss
2) Have you done any dexascans/bodyspecs to measure your lean mass percentage before and after your loss
3) Did you take any steps to reduce the muscle loss?
4) with 35% loss, what BMI are you at?
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Super responders unite, I'm down 32% and shooting for 36% before I hit maintenance. I only made it about half way up the dosage chart before I had to back off due to losing too rapidly (!!). I took a 3 month maintenance and am back to losing again, it's been life changing.
The other wild thing is general health improvement - all of my bloodwork has gone from questionable to better than standard - closer to ideal values than I would ever expect. Liver values, cholesterol, lipids, blood pressure, everything. I expected them to improve but not to the degree that they have, my LDL has gone down by 60%. Actuarial tables say it's given me another ~10 years of probable lifespan, and even more if you think in healthspan.