I lived on the top floor of a 12 story dorm with radiators. Everyone on our floor would have the windows open all the time. When it was warm out, we needed any fresh air. When it was cold out, the radiators would be so hot, the fresh air balanced it. Down about 6th floor was nice though.

But, to answer the OP, putting conditioning on the perimiter of the building keeps the interior temperature gradient minimal. If you deliver conditioning to the center of the building, the perimeter approaches outside temperatures (depending) and you have a big gradient and much less comfort. There's also better heat transfer when you deliver conditioning at bigger delta T, which pushes towards the perimeter as well... But it means more ducting/piping. And if you're using fireplaces for heat, it's complex because classically fireplaces pull in air from the conditioned space, and make up air comes from outside, you really want that fire to warm up surfaces to get radiative heat; burying it in the center of the building will be better than having it off in the corner; but it you use outside air for combustion, you can put it on the perimeter.