- If it runs Python and pip/pipx, and you can pull in the required packages via pip/pipx, it'll run Reticulum.

- On 32-bit x86 platforms it has to build the PyCA/cryptography module, but works fine after it does that.

- Reticulum supports a number physical interfaces, serial is one of them. It of course has the "RNode" intefaces for LoRa radios. For Ethernet, there is "AutoInterface" which uses IPv6 autoconfiguration for peer discovery and IPv6 UDP for transport but doesn't rely on DNS, DHCP, or anything else. If your PC, phone, or other involved devices on the same network have IPv6 enabled and no filtering is happening on layer 2 then it's dead simple - any device there will see announces from others and be able to transact with you not doing much more than spinning up MeshChat.

- Other interface types are TCP client, TCP server, IPv4 UDP, I2P, and a pipe interface. The pipe interface is interesting as it's basically stdin/stdout to an executable of your choice, so you can use that to make Reticulum available over really anything you could dream up, such as an SSH tunnel.