Last time the US won a war without the assistance of any allies (and not against yourself), it was 1848 and you were fighing Mexico.
The US economy is only the largest if you don't adjust for purchasing power, at which point the US and EU are in joint second place way behind China, and separated from each other by a rounding error despite Brexit.
If the US wants to go alone, sure we'd miss you, but it's welcome to go in peace… so long as it doesn't steal Greenland on the way out.
This is effectively a defection, which in game theory may make sense but we're talking about a lot of lives and the established world order here. You mess with that at your peril, the idea that you can just pretend we're playing a game of Risk here is idiotic. But once you get past a certain point momentum takes over. We may already be there, maybe not quite, but this is about as dangerous as it has been in a very long time.