I might be able to use this, especially in LLMs where I ask them to give me things in code fences all the time. If I ask for markdown in a code fence, it all falls apart. If, however, I asked for markdown in a ~~~ code fence, or even ~~~~~, all would be right with the world, since they typically use ```.
I was debugging code last night that uses ~~~ as a delimiter in a string. At least, as you say, you can go crazy and use ~~~~~ to get around it.