https://www.science.org/doi/10.1126/science.adx6649
A small molecule inhibitor of 15-hydroxy prostaglandin dehydrogenase causes cartilage regeneration. I hope they fast-track it to human trials.
They already have a human trial in progress...
It is being trialed to prevent muscle weakness and some of those patients will have arthritis and they can be assessed for statistical improvement.
Same thing happened with GLP1
"Phase 1 clinical trials of a 15-PGDH inhibitor for muscle weakness have shown that it is safe and active in healthy volunteers. Our hope is that a similar trial will be launched soon to test its effect in cartilage regeneration" - Helen Blau, Baxter Laboratory for Stem Cell Biology & the Donald E. and Delia B. Baxter Foundation Professorship