Sure, you need a tiny bit of asm to do the actual syscall. That's not what I'm talking about. Most syscalls are easy to wrap, clone is slightly harder but doable (as evidenced by glibc). clone3 is for all intents and purposes impossible to write a general C wrapper for. It allows you to create situations such as threads that share virtual memory but not file descriptors, or vice-versa. That is, it can leave the caller in a situation that violates core assumptions by libc.
You're mixing things up. C the language doesn't know about virtual memory or file descriptions. Those are OS features.