If you look at enough cheapo/handmade circuit boards you'll notice they often look like the bottom one. Cramped, untidy, or otherwise odd trace layout, poor part placement, poor soldering. The top one - although looking less space efficient because there's more going on - is layed out better. The design just flows in a way amateur designs don't.

If you look closely at the bottom one, almost all the components are slightly askew, while the top one has everything at neat 90 degrees. And a smaller IC almost always means the more modern/expensive IC. Same for the other components. In fact, the top one has a much higher component count, the small components just don't show up well (look at the pads though).