So what we need is essentially a "libc virtualization".

But Musl is only available on Linux, isn't it? Cosmopolitan (https://github.com/jart/cosmopolitan) goes further and is available also on Mac and Windows, and it uses e.g. SIMD and other performance related improvements. Unfortunately, one has to cut through the marketing "magic" to find the main engineering value; stripping away the "polyglot" shell-script hacks and the "Actually Portable Executable" container (which are undoubtedly innovative), the core benefit proposition of Cosmopolitan is indeed a platform-agnostic, statically-linked C standard (plus some Posix) library that performs runtime system call translation, so to say "the Musl we have been waiting for".